GPAT 2024 Question Paper is available for download here. National Board of Examinations in Medical Sciences (NBE) conducted GPAT 2024 exam on June 8, 2024. GPAT 2024 question paper consists a total of 125 questions divided among 5 sections.
GPAT 2024 Question Paper with Answer Key PDF
GPAT 2024 Questions with Solutions
SECTION A
Question 1:
The below structure represents the drug:
![drug]()
- (A) Isoprenaline
- (B) Amphetamine
- (C) Norepinephrine
- (D) Salbutamol
Question 2:
Chikusetsu saponin is present in:
- Senega
- Quillia
- Ginseng
- Liquorice
Question 3:
What is the best time to collect the medicinal bark material?
- Post flowering
- Before the leaf falls
- Pre flowering
- After the leaf falls
Question 4:
Which of the following steps are not involved in gravimetric analysis:
- Precipitation
- Indicator
- Digestion
- Filtration
Question 5:
Which of the following is a meta directing group?
- F
- NHCH3
- NH2
- CF3
Question 6:
The Wilson's disease is a rare inherited disorder due to accumulation in brain, liver, and other vital organs of:
- Iodine
- Copper
- Iron
- Calcium
Question 7:
The starting raw material for synthesis of lignocaine is:
- 2,6-Xylidine
- p-Nitroacetophenone
- 4-Amino-3-Nitroanisole
- 4-Chlorobenzyl cyanide
Question 8:
Coating of Eudragit NE40D on tablets is done to prepare:
- Sublingual tablets
- IR tablets
- CR tablets
- Buccal tablets
Question 9:
During compression of tablets, dwell time is:
- Time it takes for the punches to punch tablet
- Time it takes for the punches to stop moving vertically and to achieve maximum penetration in the die under the primary compression rollers
- Time it takes for the punches to eject the tablets
- Time it takes for the punches to eject tablet under the primary compression rollers
Correct Answer: (2) Time it takes for the punches to stop moving vertically and to achieve maximum penetration in the die under the primary compression rollers
View Solution
Question 10:
According to the SAR of Chloroquine, electron:
- Withdrawing group at 6th position of the quinoline ring is important for the inhibition of hemozoin formation
- Donating group at 7th position of the quinoline ring is important for the inhibition of hemozoin formation
- Donating group at 6th position of the quinoline ring is important for the inhibition of hemozoin formation
- Withdrawing group at 7th position of the quinoline ring is important for the inhibition of hemozoin formation
Correct Answer: (4) Withdrawing group at 7th position of the quinoline ring is important for the inhibition of hemozoin formation
View Solution
Question 11:
Size of a pilot plant batch is:
- 1⁄10th of marketing batch
- 1⁄10th of production batch
- 1⁄4th of marketing batch
- 1⁄4th of production batch
Question 12:
Nitrostat® is an example of:
- CR tablet
- Bolus tablet
- Sublingual tablet
- Effervescent tablet
Question 13:
The dried juice of Pterocarpus marsupium belongs to the family:
- Leguminosae
- Asteraceae
- Rosaceae
- Liliaceae
Question 14:
Spin Quantum number of 13C NMR is:
- 1⁄4
- 1⁄2
- 3⁄2
- 5⁄2
Question 15:
The rate limiting step for the absorption of controlled release tablet is the:
- Metabolism of the drug
- Excretion of the drug
- Dissolution of the drug
- Distribution of the drug
Question 16:
Which antibiotic undergoes light catalysed autoxidation:
- Polyene antibiotics
- Beta lactum antibiotics
- Sugar derived antibiotics
- Macrolide antibiotics
Question 17:
Which of the following is not a method for solubility enhancement:
- Crystallization
- Co-solvency
- Salt formation
- Hydrotropy
Question 18:
Schedule T of Drugs and Cosmetics Rules, 1945 deals with:
- GMP for ASU drugs
- GLP and requirement of premises and equipments
- GMP for Homeopathy medicine
- GMP for Pharmaceutical product
Question 19:
The key intermediate for the biosynthesis of C6-C3 units is:
- Pyruvic acid
- Shikimic acid
- Dehydroquinic acid
- Mevalonic acid
Question 20:
Rancidity of oil is detected by:
- Saponification value
- Iodine value
- Peroxide value
- Acid value
Question 21:
Which one of the following enzymes comprises a major part of enzyme-linked receptors:
- Receptor Histidine Kinase
- Receptor Threonine Phosphatase
- Receptor Serine Phosphatase
- Receptor Tyrosine Kinase
Question 22:
Core tablet coated with cellulose acetate phthalate has been administered to a patient. Where do you expect the drug to be released:
- Liver
- Intestine
- Oral cavity
- Stomach
Question 23:
Examples of BCS class III drugs are:
- Acyclovir, Atenolol, Captopril
- Taxol, Ellagic acid, Aspirin
- Aspirin, Paracetamol, Amoxycillin
- Chloroquine, Diltiazem, Metoprolol
Question 24:
The bloom strength is directly proportional to:
- Measure of the strength and stiffness of the gelatin
- Density
- Molecular weight
- Viscosity
Question 25:
Famotidine contains:
- Thiazole ring
- Imidazole ring
- Pyrrole ring
- Furane ring
SECTION B
Question 1:
An elixir contains 47% v/v alcohol, what is the proof spirit according to USP:
- 70%
- 82%
- 63%
- 91%
Question 2:
Alfa Alfa belongs to which of the following families:
- Convolvulaceae
- Leguminosae
- Liliaceae
- Acanthaceae
Question 3:
Name the following drug molecule:
![Drug Molecule]()
- Mechlorethamine
- Chlorambucil
- Vincristine
- 6-Mercaptopurine
Question 4:
The biological name of Indian Bdellium is:
- Commiphora mukul
- Commiphora berryi
- Commiphora wightii
- Commiphora molmol
Question 5:
According to Oppenauer Oxidation reaction, oxidation of secondary alcohol to ketone by reagent (X) in acetone takes place, what is "X":![Chemical Reaction]()
- Aluminium Hydroxide
- Amalgamated Zinc and Conc. HCl
- Conc. H2SO4
- Aluminium t-butoxide
Question 6:
Which of the following climatic zones can be categorized into the hot and dry zone?
- Zone-II
- Zone-I
- Zone-III
- Zone-IV
Question 7:
The IUPAC name of tartaric acid is:
- 1,3-dihydroxybutane-1,4-dioic acid
- 2,3-dihydroxybutane-1,4-dioic acid
- 2,3-dihydroxy-4-butanoic acid
- 2,2-dihydroxy-4-butanoic acid
Correct Answer: (2) 2,3-dihydroxybutane-1,4-dioic acid
View Solution
Question 8:
H1 receptor protein in humans is made up of:
- 487 Aminoacids
- 390 Aminoacids
- 445 Aminoacids
- 359 Aminoacids
Question 9:
Based on the rheological behavior of fluid, all of the following shows time independent property, except:
- Plastic
- Anti-thixotropic
- Pseudoplastic
- Non-newtonian
Question 10:
Etoposide and Teniposide are the semi-synthetic derivatives of:
- Podophyllotoxin
- Digoxin
- Vincristine
- Taxol
Question 11:
Which of the following is/are in-process QC test(s) for tablets:
- Zeta-sizing Test
- Hardness, Friability, Average weight
- Drug content, Puncture Test
- Dissolution Test
Correct Answer: (2) Hardness, Friability, Average weight
View Solution
Question 12:
Which is the active form of Ganciclovir?
- Phosphate
- Tetraphosphate
- Biphosphate
- Triphosphate
Question 13:
Which of the following volatile oils are heavier than water:
- Cumin
- Cinnamon
- Fennel
- Lemongrass
Question 14:
Which of the following mills is based on the mechanism of impact and attrition for size reduction:
- Roller mill
- Fluid energy mill
- Hammer mill
- Colloid mill
Question 15:
Which of the following is Phase-II metabolism reaction:
- Reduction
- Acetylation
- Hydrolysis
- Oxidation
Question 16:
Antioxidant which is obtained from a desert plant and shows synergistic action with citric acid is:
- Maleic acid
- BHA
- Tocopherols
- Nordihydroguaiaretic acid (NDGA)
Correct Answer: (4) Nordihydroguaiaretic acid (NDGA)
View Solution
Question 17:
Calculate the λmax of the following molecule:
![Molecule Image]()
- 283 nm
- 273 nm
- 234 nm
- 244 nm
Question 18:
The most suitable test for digitoxose is:
- Hager's test
- Dragendrof's test
- Baljet test
- Keller-Kiliani
Question 19:
Which of the following protective colloids has a high gold number?
- Acacia
- Tragacanth
- Albumin
- Gelatin
Question 20:
The equivalent weight of Potassium permanganate in acidic medium is:
- 31.6
- 51.6
- 41.6
- 21.6
Question 21:
Match the following disease with their test for detection:
Disease |
Diagnostic tests |
P. Tuberculosis |
(i) Lepromin test |
Q. AIDS |
(ii) ELISA |
R. Syphilis |
(iii) Mantoux test |
S. Leprosy |
(iv) Kahn's test |
- P(iv), Q(ii), R(iii), S(i)
- P(iii), Q(ii), R(iv), S(i)
- P(i), Q(ii), R(iii), S(iv)
- P(iv), Q(i), R(ii), S(iii)
Question 22:
Which of the following type of viscometer is used for the measurement of viscosity of a Newtonian fluid:
- Cup and bob viscometer
- Brookfield's viscometer
- Pycnometer
- Ostwald viscometer
Question 23:
The composition of "Lindlar catalyst" is:
- Amalgamated Zinc and HCl
- NH2NH2 and KOH
- Palladium with calcium carbonate
- Palladium with Sodium carbonate
Correct Answer: (3) Palladium with calcium carbonate
View Solution
Question 24:
5-Fluorouracil, an anti-metabolite used in cancer treatment, is activated to:
- 5-fluoro-2-oxyuridylic acid
- 3-fluoro-3-deoxyuridylic acid
- 3-fluoro-3-oxyuridylic acid
- 5-fluoro-2-deoxyuridylic acid
Question 25:
Which of the following drugs has a 1,3,4-thiadiazole ring system?
- Dichlorophenamide
- Spironolactone
- Acetazolamide
- Furosemide
SECTION C
Question 1:
Leprosy is a:
- Bacterial disease
- Viral disease
- Fungal disease
- Metazoal disease
Question 2:
The appendicular skeleton in an adult consists of:
- 126 bones
- 206 bones
- 80 bones
- 120 bones
Question 3:
Histogram can be drawn only for:
- Cumulative frequency distribution
- Discrete frequency distribution
- Continuous frequency distribution
- Relative frequency distribution
Correct Answer: (3) Continuous frequency distribution
View Solution
Question 4:
Murmurs are generally heard in disorders affecting the following:
- SA nodes
- Pulmonary vein
- AV nodes
- Heart valves
Question 5:
Which of the following is first prodrug for sulfonamide:
- Prontocil
- Sulfamidochrysodine
- Sulfatrim
- Trimethoprim
Question 6:
Which oral hypoglycemic agent increases the levels of incretin hormone by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4):
- Metformin
- Pioglitazone
- Sitagliptin
- Glipizide
Question 7:
Biological activity of synthetic adrenaline is almost:
- 25% of S-adrenaline
- 25% of R-adrenaline
- 50% of S-adrenaline
- 50% of Natural R-adrenaline
Question 8:
Central Government approved factory premises where Opium alkaloids are processed is situated at:
- Ghazipur and Kota
- New Delhi and Ghaziabad
- Gwalior and Kota
- Neemuch and Ghazipur
Question 9:
Tetracycline undergoes epimerization at C4 between pH 4-8 to give:
- Isotetracycline
- Doxycycline
- Epitetracycline
- Nortetracycline
Question 10:
The etiology of jaundice could be haemolytic anaemia if:
- Unconjugated bilirubin is found equal to conjugated bilirubin
- Increase in IgE level
- Conjugated bilirubin is found more than unconjugated bilirubin
- Unconjugated bilirubin is found more than conjugated bilirubin
Correct Answer: (4) Unconjugated bilirubin is found more than conjugated bilirubin
View Solution
Question 11:
Precursor for corticosteroids synthesis is:
- Phenanthrene
- 1,2-Cyclopentophenanthrene
- 1,2-Cyclopentodihydrophenanthrene
- Cholesterol
Question 12:
Which one of the following diseases is caused by the deficiency of niacin:
- Anemia
- Night Blindness
- Pellagra
- Scurvy
Question 13:
Enzyme commonly targeted by drugs to treat hypertension is:
- Cyclooxygenase (COX)
- HMG-CoA reductase
- Angiotensin-converting enzyme (ACE)
- Monoamine oxidase (MAO)
Correct Answer: (3) Angiotensin-converting enzyme (ACE)
View Solution
Question 14:
How many optical isomers are possible for lactic acid:
- 4
- 0
- 6
- 2
Question 15:
If one event is unaffected by the outcome of another event, the two events are said to be:
- Mutually exclusive
- Dependent
- Either dependent or independent
- Independent
Question 16:
Which functional group in drug molecules is most likely to undergo phase I metabolic oxidation by cytochrome P450 enzymes:
- Ester group
- Amide group
- Hydroxyl group
- Methyl group
Question 17:
Which ring of warfarin is essential for its therapeutic activity:
- Purine
- Pyrimidine
- Lactone
- Coumarin
Question 18:
Following are the examples of negative feedback system except:
- Body temperature regulation
- Blood glucose maintenance
- Blood clotting
- Blood pressure maintenance
Question 19:
Which of the following is called as cell-mediated (delayed) hypersensitivity:
- Type II hypersensitivity
- Type I hypersensitivity
- Type III hypersensitivity
- Type IV hypersensitivity
Question 20:
Which ionization technique in mass spectrometry is most suitable for large biomolecules like proteins:
- Chemical Ionization (CI)
- Physical Ionization (PI)
- Electron Impact (EI)
- Electrospray Ionization (ESI)
Question 21:
Which of the following hormone is not secreted by the human placenta:
- Estrogen
- hCG
- LH
- Progesterone
Question 22:
Which of the following is an aryl acetic acid derivative:
- Salsalate
- Ibuprofen
- Aspirin
- Mefenamic acid
Question 23:
Melatonin is secreted by:
- Thyrotrophs
- Gonadotrophs
- Pineal gland
- Adrenal gland
Question 24:
Which hormone stimulates red blood cell production:
- Vasopressin
- Erythropoietin
- Erythrocytin
- Prolactin
Question 25:
Which of the following drug does NOT require therapeutic drug monitoring:
- Digitoxin
- Phenytoin
- Gentamicin
- Acetaminophen
SECTION D
Question 1:
The short-acting anticholinesterase drug is:
- Physostigmine
- Edrophonium
- Ecothiophate
- Neostigmine
Question 2:
Which among the following is an example of a high shear mixer:
- Turbine mixer
- Jet mixer
- Sigma blade mixer
- Nauta mixer
Question 3:
In a homologous series of any general anesthetic, increasing the chain length increases the lipid solubility and produces a corresponding increase in anesthetic potency, is proposed by:
- John Pemberton
- Meyer - Overton
- Hubert Humphrey
- Meyer - Philip
Question 4:
Influenza viruses are RNA viruses and belong to which family:
- Orthomyxoviridae
- Papoviridae
- Retroviridae
- Parvoviridae
Question 5:
Two drugs producing the same clinical effects and safety profile when administered to patients are considered:
- Minimum Toxic Concentration (MTC)
- Minimum Effective Concentration (MEC)
- Therapeutic equivalent
- Therapeutic window
Question 6:
Aerobic dehydrogenase in biological oxidation contains:
- NAD
- NADH
- NADP
- FMN & FAD
Question 7:
Match the following antibodies with their correct description:
Antibody |
Description |
P. IgE |
(i) Cross the placenta |
Q. IgG |
(ii) Dominant antibody produced in immune responses |
R. IgM |
(iii) It is found in the mother's milk |
S. IgA |
(iv) Responsible for autoimmune responses including allergies |
- P(i), Q(iii), R(ii), S(iv)
- P(i), Q(ii), R(iii), S(iv)
- P(iv), Q(ii), R(iii), S(i)
- P(iv), Q(i), R(ii), S(iii)
Question 8:
Plasma protein bound drugs are:
- Pharmacodynamically active
- Pharmacokinetically inert
- Pharmacokinetically and Pharmacodynamically inert
- Pharmacodynamically inert
Question 9:
Which of the following equipment measures weight variation using reflected energy:
- Rotofill
- Vericap-1200
- Rotosort
- Rotoweight
Question 10:
Which among the following is not the process of drug degradation:
- Photolysis
- Decarboxylation
- Hemolysis
- Hydrolysis
Question 11:
The term of a patent granted under the Indian Patent Act is:
- 20 Years
- 10 Years
- 30 Years
- 40 Years
Question 12:
Choose the incorrect statement regarding Cathode rays:
- Cathode rays produce X-rays
- Cathode rays are electromagnetic waves
- Cathode rays travel in a straight route
- Cathode rays are fast electrons
Correct Answer: (2) Cathode rays are electromagnetic waves
View Solution
Question 13:
Among the following, which is known as "SPIRIT OF SALT”?
- Nitric acid
- Boric acid
- Hydrochloric acid
- Thioglycolic acid
Question 14:
Partial hydrogenation of vegetable oils in the presence of Ni catalyst at 200°C gives:
- Butter
- Vanaspati ghee
- Cheese
- Margarine
Question 15:
As per Bronsted-Lowry concept, acid is defined as:
- Electron pair acceptor
- Any substance/molecule that can accept a proton
- Any substance/molecule that can donate a proton
- Electron pair donor
Correct Answer: (3) Any substance/molecule that can donate a proton
View Solution
Question 16:
Which of the following is a correct expression of average particle size with the value of p = 1 (size index) and frequency index f = 2:
A |
B |
C |
D |
din= Σnd2⁄Σnd3 |
din= Σnd2⁄Σnd2 |
dsl= Σnd3⁄Σnd2 |
dsl= Σnd3⁄Σnd2 |
- B
- C
- D
- A
Question 17:
Which of the following is a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist:
- Ezetimibe
- Niacin
- Colesevelam
- Gemfibrozil
Question 18:
The given equation represents which law:
E = Kk ln d1⁄d2
- Rittinger's law
- Bond's law
- Fick's law
- Kick's law
Question 19:
In which limit test is Thioglycolic acid used:
- Limit test for arsenic
- Limit test for sulphate
- Limit test for iron
- Limit test for chloride
Question 20:
Who has the power to fix the ceiling price of scheduled formulations:
- Director General Health Services
- Pharmacy Council of India
- National Medical Commission
- National Pharmaceutical Pricing Authority
Correct Answer: (4) National Pharmaceutical Pricing Authority
View Solution
Question 21:
Which of the following is not a GABA derivative:
- Pregabalin
- Vigabatrin
- Gabapentin
- Rufinamide
Question 22:
A hypothesis stipulating that there is no difference between the situations, groups, and outcomes is called:
- Hypothesis of association
- Null hypothesis
- Hypothesis of differences
- Alternative hypothesis
Question 23:
How many Pharmacists are required for a hospital having up to 300 beds:
- 8
- 10
- 15
- 5
Question 24:
Which of the following is easily nitrated using a mixture of HNO3 and H2SO4:
- Toluene
- Fluorobenzene
- Chlorobenzene
- Nitrobenzene
Question 25:
If the spin of the electrons in the excited state are parallel, it is called as:
- Doublet state
- Triplet state
- Singlet state
- Parallel state
SECTION E
Question 1:
The amount of air that moves in or out of the lungs with each respiratory cycle is:
- Inspiratory reserve volume
- Expiratory reserve volume
- Tidal volume
- Residual volume
Question 2:
Virus-mediated transfer of host DNA from one cell to another cell is known as:
- Transduction
- Integration
- Transformation
- Transcription
Question 3:
What should be the log P value for an ideal drug candidate for transdermal permeation:
- Below 1
- 1-3
- 5-7
- Above 7
Question 4:
Which of the following formula for calculating child dose is based on body weight:
- Clark's formula
- Fried's formula
- Young's formula
- Dilling's formula
Question 5:
Salivary amylase helps in digestion of which of the following nutrients:
- Fats
- Vitamins
- Starch
- Proteins
Question 6:
In the drying process, which of the following parameters is the same as the adiabatic saturation temperature:
- Absolute humidity
- Dew point
- Relative humidity
- Wet bulb temperature
Question 7:
What is the proposed mechanism of action of artemisinin in the treatment of malaria:
- Inhibition of dihydrofolate reductase, interfering with folate synthesis
- Blocking of the Plasmodium falciparum ATPase, disrupting ion homeostasis
- Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
- Inhibition of the heme polymerase enzyme, causing accumulation of toxic heme
Correct Answer: (3) Generation of reactive oxygen species (ROS) by cleavage of the endoperoxide bridge, leading to parasite death
View Solution
Question 8:
The optimum temperature for rapid growth of mesophiles is:
- 40°C to 50°C
- 50°C to 60°C
- 15°C to 20°C
- 25°C to 40°C
Question 9:
The fluoroquinolones act by:
- Inhibiting folic acid synthesis, reducing nucleotide production and DNA synthesis
- Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA
- Disrupting peptidoglycan cross-linking, weakening the bacterial cell wall
- Inhibiting ribosomal subunits, leading to the cessation of protein synthesis
Correct Answer: (2) Inhibiting DNA gyrase and topoisomerase IV, causing supercoiling and fragmentation of bacterial DNA
View Solution
Question 10:
The cranial nerve that regulates the heartbeat is:
- IX
- VII
- X
- VIII
Question 11:
Which of the following is a causative organism for Syphilis:
- Vibrio cholerae
- Treponema pallidum
- Bacillus pertussis
- Clostridium tetani
Question 12:
Coomb's test is used for detection of:
- Yellow fever
- Syphilis
- Typhoid
- Antiglobulin
Question 13:
In Michaelis-Menten equation when Km = C:
- The rate of process is equal to half of maximum rate
- Indicates zero-order process
- The rate process occurs at a constant rate
- Equation becomes identical to first-order elimination of drug
Correct Answer: (1) The rate of process is equal to half of maximum rate
View Solution
Question 14:
Which of the following is NOT a Class 1C anti-arrhythmic drug
- Propafenone
- Mexiletine
- Flecainide
- Moricizine
Question 15:
Which of the following is an example of physical incompatibility:
- Alkaloidal incompatibility
- Liquefaction
- Drug interaction
- Error in dosage form
Question 16:
Which of the following is a Partial Fatty acid oxidation (pFox) inhibitor:
- Trimetazidine
- Atosiban
- Verapamil
- Nicardipine
Question 17:
Renin is released from:
- Hepatocytes of liver
- Beta-cells of pancreas
- Microglial cells
- Juxtaglomerular cells (JGCs) of kidney
Correct Answer: (4) Juxtaglomerular cells (JGCs) of kidney
View Solution
Question 18:
Which of the following cranial nerve is instrumental in motor function:
- Vestibulocochlear
- Olfactory
- Accessory
- Optic
Question 19:
The most common neoplasm in patients with AIDS is:
- Carcinoma of breast
- Acute myeloid leukaemia
- Adenocarcinoma
- Kaposi sarcoma
Question 20:
The Phase in which two identical copies of DNA are formed is:
- M phase
- G2 phase
- G1 phase
- S phase
Question 21:
Progressive loss of bone that occurs in osteoporosis is an example of:
- Atrophy
- Hyperplasia
- Hypertrophy
- Metaplasia
Question 22:
The visible coloured ring of the eye is called:
- Lens
- Retina
- Cornea
- Iris
Question 23:
Sarcoma is the cancer of:
- Plasma cells
- Glands
- Connective tissues
- Epithelium
Question 24:
Outer covering of the testes is:
- Tunica albuginea
- Tunica vaginalis
- Tunica media
- Tunica vasculosa
Question 25:
Which of the following is the best technique for detecting HIV:
- Widal test
- Real-time PCR
- Polymerase chain reaction
- Reverse transcriptase-PCR
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